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After incubation, cells were exposed to the mix, in a final concentration of 30 nM siRNA, according to the manufacturers protocol

Final Thoughts: Generally speaking, microneedling combined with isotretinoin is not advised because of the higher risk of skin irritation, scarring, and delayed healing

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Funding The EMPIRE innovative program, The State University of New-York

Similarly, individuals whose lesions show high expression of senescence markers like p16INK4a or SA--Gal activity might be prioritized for senolytic treatments, ensuring a more personalized and effective approach