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Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase
but the affinity for the p75NTR receptor is lower than for TrkB
selective and orally bioavailable dual inhibitor of the IGF-1 receptor and insulin receptor (IR) with IC50s of 35 and 75 nM
Inhibits acidification of organelles such as lysosomes and the Golgi apparatus
Lysosomes exhibit a relatively large size
Sitagliptin Pack Size:100 mg Acts by forming a hemiacetalSitagliptin (MK 0431) is a potent and orally active inhibitor of DPP4 with an IC50 of 19 nM in Caco 2 cell extracts.
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