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2 , 59 , 60 , 61 These DNA changes almost all are missense mutations leading to single amino acid substitutions in the enzyme

Noteworthily, sometimes such methods of treatment are not achievable because the tumor cells have certain features such as being capable of growing, invading, and metastasizing frantically [91]

The underlying physiological pathways are not well understood

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Conclusion: This study emphasizes the importance of patients, caregivers, healthcare providers education on DOAC treatment importance and consequences