AOD-9604 has no approved therapeutic use anywhere in the world
However, Epithalon should only be used under medical supervision, as is the case with all peptide therapies
Its relevance to neuropathy comes through serotonin synthesis promotion and neuroprotective gene expression modulation
DHODH activity is essential for proliferating cells owing to their increased demand for nucleotides, and DHODH inhibition has long been studied as a therapeutic strategy in autoimmune diseases (for example, via leflunomide) and cancer, where it can lead to cell cycle arrest, DNA damage and replication stress 42,44,45
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