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Based on these findings, Eisai conducted a Phase 2/3 trial (NCT00444613) in Japan to evaluate the safety and efficacy of ultrahigh-dose methylcobalamin injections in 373 adults whose ALS symptoms began up to three years before enrollment

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Few high-quality randomized trials have investigated differentiated approaches to nonoperative treatment, which include medications, physical therapy, bracing, alternative/complementary medicine, and epidural injections