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In vitro experiments showed FOXO4-DRI to be more potent against senescent cells in which SASP was transiently boosted by recombinant IL1/ or LPS, whereas an IL1 receptor antagonist or the general anti-inflammatory drug Cortisol reduced its potency (Fig

215 Cyst(e)inase degrades extracellular cysteine and cystine and leads to decreased levels of intracellular cysteine and glutathione, which profoundly affects the redox potential of cancer cells 216 and counteracts the essential role of cysteine in cancer cells

10.1523/JNEUROSCI.4979-06.2007 J

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Always swab the top of the vial with an alcohol wipe, rubbing alcohol or 95% ethanol before use