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The HSD17B1, HSD17B3, ARK1C3 (also known as HSD17B5), HSD17B7, HSD17B12, and RDH11 (also known as HSD17B15) enzymes all function in some capacity in the metabolism of steroids

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That rigor cuts both ways for anyone tempted to read the trials optimistically: the same design that credibly demonstrated the GH/IGF-1 effect also credibly demonstrated the absence of the hoped-for clinical benefits

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