NMDA receptors open their cation channels only selectively even when their primary glutamate (Glu) ligand is bound, in a manner gated by both membrane depolarization and a number of co-transmitters, including several nitrergic co-transmitters that will be revisited throughout this review (Figure 2)
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This method may lead to more immediate and potent effects on increasing glutathione levels in the body
Research use therefore focuses on mechanism, target validation, and combinatorial experiments (e.g., with dietary change or NAD precursors) [14,8,9]
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