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Mean CSF lactate levels were higher in ME/CFS and FM patients compared with HC, but these measures did not sufficiently distinguish between the two conditions

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The animal evidence is consistent with the mechanistic findings

The AnglV analog D-Nle-Tyr-Ile-NH-(CH 2 ) s -CONH 2 has a much longer circulating half- life than Norleual (Nle-Tyr-Leu-i^CHj-NH^-His-Pro-Phe (SEQ ID NO: 1)) As anticipated from the in- vitro blood stability data, D-Nle-Tyr-Ile-NH-(CH 2 )5- CONH 2 exhibited an extended in vivo elimination half-life of 1012 min after IV injection in rats

Manufacturer-documented storage conditions: Pfizer/Hospira prescribing information specifies controlled room temperature, defined as 20-25C (68-77F) with excursions permitted to 15-30C (59-86F)