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Mechanistically, that is interesting because it suggests the peptide may not act identically across cell contexts

Hecht F, Pessoa CF, Gentile LB, Rosenthal D, Carvalho DP, Fortunato RS

Moreover, the regulatory effects of pathway-level interventions tend to attenuate along the signaling cascade and are highly dependent on the disease microenvironment, rendering the ultimate modulation of specific ATFs indirect and unpredictable

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6.25200 g/mL) were efficiently internalised into the cytoplasm of the cells, often localising near the nucleus, and induced increased proliferation of Bhas 42 cells in both phases of the assay (initiation and promotion), particularly at higher concentrations