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Furthermore, to refine the experimentally determined structural model and explore interaction dynamics, we conducted extensive MD simulations

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Step 10: Establish Reassessment Timeline Every stack should include a review checkpoint

TB-500 / T4 also rests mostly on decades of preclinical work, but the T4 compound class has reached human clinical study in at least one delivery context: a topical T4 ophthalmic candidate (RGN-259) was evaluated in human Phase 2 trials for corneal/dry-eye endpoints (Crockford et al., Ann N Y Acad Sci 2010)