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Artemisinin and its derivatives can induce Ferroptosis by increasing reactive oxygen species

A catalytic triad is formed by the selenocysteine in the active site with tryptophan and glutamine: this activates the selenium portion and neutralizes peroxides [135]

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Therefore, the management of CRF requires multidisciplinary collaboration and comprehensive measures, including symptomatic treatment, psychological intervention and exercise rehabilitation, to improve the quality of life of patients