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During this period, brain growth is rapid, increasing the susceptibility to influences from the environment.27 This is also the period when most of the myelination of the brain occurs.9 In infants, moderate and severe vitamin B 12 deficiency has been associated with demyelination and brain atrophy.28 29 Little is known about the consequences of maternal vitamin B 12 deficiency for early brain myelination, neurodevelopment and cognitive function