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Studies using fluorescence microscopy and co-immunoprecipitation techniques have visualized this molecular displacement mechanism, confirming target engagement in senescent but not healthy cells

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Cell Mol Life Sci 59:627647 Alonso-Gonzalez C, Mediavilla D, Martinez-Campa C, Gonzalez A, Cos S, Sanchez-Barcelo EJ (2008) Melatonin modulates the cadmium-induced expression of MT-2 and MT-1 metallothioneins in three lines of human tumor cells (MCF-7, MDA-MB-231 and HeLa)