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Treatment duration critically influences post-discontinuation outcomes with 6-12 month courses creating durable structural improvements supporting ongoing enhanced collagen synthesis without continuous peptide presence, while 2-3 month treatments produce temporary stimulation requiring continuous or cyclical application for maintaining optimal results

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In a review titled "Peptides, Genome, and Aging," Khavinson states that treatment with both epitalon and epithalamin resulted in increased telomere lengths in the blood cells of patients between 60 and 65 years of age as well as 75 and 80 years of age

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Advancements in drug development have led to the discovery of newer, better-tolerated platinum-based drugs with confirmed pro-aging effects [45, 77]