another insists on sub-zero temperatures
Stapleton LM, Steele AN, Wang H, Lopez Hernandez H, Yu AC, Paulsen MJ, et al
While their primary mechanism involves inhibiting glucose reabsorption in the kidney, their cardioprotective effects in MIRI are thought to be mediated by multiple pathways, including a significant contribution from reducing oxidative stress and inflammation (Pham et al., 2024
Along with oxidative stress, these abnormal molecular changes lead to impaired mitochondrial respiratory function, ATP depletion, and various destructive cellular processes, such as mitochondrial fission, mitophagy, and programmed cell death, as we discuss below
2024;10:e8da1557