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People following a vegan diet or strict vegetarian diet are at higher risk of B12 deficiency, since B12 occurs almost exclusively in animal-based foods

Discussion Significance of the study To our knowledge, this is the most comprehensive network meta-analysis comparing the efficacy of SL, IM, and oral routes of administration of vitamin B12 in patients with vitamin B12 deficiency

These include increased energy levels, improved cognitive function, better moods, and reduced risk of certain diseases

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In such cases, supplementation is often recommended