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They have attracted substantial scientific interest due to their potent pharmacological activities, including improving glucose metabolism [44, 127], acting as antileishmanial agents [64], and inhibiting inflammatory factors [250]

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doi: 10.1186/s12991-020-00263-w 68

By molecular simulation, we have previously shown that YMU1 acts on the catalytic pocket of TMPK, which causes the expulsion of the lid domain to give an open conformation that inhibits the catalytic process 19

In a paper recently published in the Journal of Dental Research (April 2025) , the researchers showed that an anti-senescence therapy or senotherapy, consisting of an enzyme inhibitor called dasatinib and a natural flavonoid plant compound called quercetin, reduced markers of senescence and associated periodontal inflammation and bone loss in lab-dish and animal models