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In a rat model using rats sensitized by peanut infusion, Shishehbor et al

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These actions were reproduced by human anti-GAD65 monoclonal Ab b78, which binds to an epitope similar to that recognized in SPS patients positive for anti-GAD65Ab [80, 81, 82]

[50,51] Potential biologics have been generated to target pro-inflammatory cytokines, such as IL-1, interferon (IFN)-, IFN-, IL-6, TNF-, IL-17, and IL-21, and several clinical trials that aim at inhibiting the activities of these mediators have been initiated