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The mouthpiece may also provide relief to people with sleep apnea a condition that blocks or pauses the airway during sleep, by promoting better quality of sleep and fever disturbances

2 The accessibility and widespread availability of APAP contribute to its high prevalence as a cause of acute liver injury

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APAP Metabolism: Mitochondrial Targeting Acetaminophen hepatoxicity is caused by the action of a reactive metabolite derived from APAP metabolism in the liver that ultimately targets mitochondrial components resulting in impaired mitochondrial function