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J Biosci Bioeng 123(5):555561

Recent Advances of Natural Polyphenols Activators for Keap1-Nrf2 Signaling Pathway

Therefore, biosynthesis and metabolism of VD are under the control of VD regulatory genes (GC/ VDBP /VD-25-hydroxylase) in the liver, while the downstream actions of the active 1,25(OH) 2 VD in muscle are mediated by glucose metabolism genes ( VDR /peroxisome proliferator-activated receptor gamma coactivator 1-alpha [ PGC-1 ]/glucose transporter type 4 [ GLUT-4 ])

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This explains the lack of tolerance and dependence liability observed in animal studies