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This proapoptotic activity is mediated predominantly through the activation of caspase-9
meaning it can transfer K+ ions across biological membranes
Working concentration in PCR mixture is 1x
are difficult to amplify
8 and 48 nM
Wortmannin HY-17514 This proapoptotic activity is mediatedWortmannin (SL 2052; KY 12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo like kinase 1 (PlK1) and Plk3 with IC50s of 5. 8 and 48 nM, respectively.
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