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Peer review Peer review information Nature Catalysis thanks Mattheos Koffas, Bengt Mannervik, Boas Pucker, Dingguo Xu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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A complementary axis involves transcriptional reinforcement of antioxidant programs, including NFE2 like BZIP transcription factor 2 (NFE2L2, also known as NRF2) signaling, which increases GPXs and further suppresses ROS-driven inflammasome activation 58

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