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59 The mechanisms of action of clinically used ASOs mainly include ribonuclease H (RNase H)-mediated degradation (Fig

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Beta cells are prone to the oxidative damage caused by production of ROS because they express limited levels of antioxidant enzymes [82]

Graves orbitopathy (GO) is the most prominent and common extrathyroidal manifestation of GD, characterized by the production and accumulation of glycosaminoglycans (especially hyaluronic acid) in the retrobulbar and periorbital tissues causing protrusion of the eyeball and restriction of ocular muscle movement ( Table 1

Furthermore, the Predicted R 2 value of 0.8736 estimates the model's predictive ability