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The same HGF plasmid (VM-202) was also evaluated in ALS patients in order to define its tolerability and safety profile (NCT02039401)

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Acknowledgements The authors are grateful for the support received from the Austrian Science Fund (FWF, P 29379-B28), the Tyrolean Science Fund (TWF, 0404/1812), the Austrian Society of Gastroenterology and Hepatology (GGH) and the European Crohns and Colitis Organisation (ECCO) (to T.E.A.)

Disulfide Bond Integrity Verification (Cys7-Cys14) Because the Cys7-Cys14 intramolecular disulfide bond is required for the lipolytic conformation, every lot is checked for disulfide bond integrity using non-reducing LC-MS or Ellman's reagent analysis