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When administered either orally, intraperitoneally, or intracerebroventricularly at various doses, Dihexa-treated rats showed significantly improved performance in both acquisition trials and probe trials measuring spatial memory retention

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Additionally, DSIP appears to be regulated by glucocorticoids, and its signaling may interact with the MAPK cascade through homology with glucocorticoid-induced leucine zipper (GILZ), suggesting potential roles in cellular stress responses