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In metabolomics, significant alterations were observed in metabolism related to arginine and proline, arachidonic acid, glutathione metabolism, and ubiquinone and other terpenoid-quinone biosynthesis pathways as CKD progressed with further metabolomic analyses revealing that variations in the distributions of pro-oxidant and toxic metabolites from the four identified metabolic pathways were observed in the feces and serum of the patients as the disease progressed

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Researchers observed that dairy cows harboring a Bifidobacterium -dominated enterotype exhibited faster recovery following LPS challenge, with accelerated restoration of SCFAs, enhanced amino acid metabolism, improved glucose homeostasis, and higher milk fat and protein content compared to other enterotypes, suggesting that intrinsic microbiome configurations may determine host resilience to inflammatory challenges 94

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10.2174/1381612824666180614082950 [DOI] [PubMed] [Google Scholar] Kato N., Kawai T., Maeda H., Nagao T., Murakami H., Miyazawa K., et al

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