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While most reported toxicity cases have been associated with industrial accidents and manufacturing errors, it is important to at least be aware of the symptoms of selenium toxicity

doi: 10.1038/srep21164 (2016)

This suggests that excessive GHK-Cu (or other copper peptides) might theoretically push skin MMP-1 concentrations beyond levels supporting healthy collagen production into ranges associated with collagen fragmentation and breakdown seen in older skin with naturally elevated MMP-1