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AN: Data curation, Investigation, Methodology, Writing original draft

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The same conclusion can be found in the work of Lee et al., who conducted a temperature modulated DSC study of melting/decomposition of D-sucrose combined with High-Performance Liquid Chromatographic analysis of the system at each treatment temperature [61], as well as in the work of Toda et al

Sorafenib [a small-molecule multi-kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFRs) rapidly accelerated fibrosarcoma (RAF) and other protein kinases] has been regarded as the standard of treatment for patients with advanced HCC since 2007 ( Tivantinib, a staurosporine derivative, is a non-ATP competitive selective small-molecule inhibitor and acts mainly as an anti c-Met inhibitor (Santoro et al., 2013)