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Cumulative evidence points at alterations in neurotransmitter systems in fibromyalgia, which influence pain perception, fatigue, sleep disturbances, and depressive as well as anxiety-related symptoms (Figure 1)

Review MTHFR and folate Mitochondrial Dysfunction Review ATP production, SOD defenses, oxidative stress and the electron transport chain

Mechanistic target of rapamycin pathway activation in rheumatic diseases

6FI and 7D, S1B)

Then, the histopathological analysis was performed and scored according to the Standardized Microscopic Arthritis Scoring of Histological sections (SMASH)