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However, the absorption rate through the gastrointestinal tract is deficient so the physicians at The HCG Institute always recommend giving it via injections

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This is consistent with studies showing that HA can improve the performance of nanoparticle-based drug formulations by extending local retention and reducing systemic absorption [1]

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Antibodies to intrinsic factor (IF) bind to IF and prevent formation of the IF-B 12 complex, further inhibiting vitamin B 12 absorption