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Tumour mutational burden LCINS generally have a markedly lower TMB (measured as non-synonymous mutations per megabase (mut/Mb)) in coding and non-coding regions compared to smoking-related lung cancers, with early studies suggesting as much as a tenfold difference 131 and a doseresponse relationship between TMB and pack-years 132 (Table 1)

Rheological and inflammatory characteristics of the muco-obstructive lung diseases are compared to determine how the defect in mucus clearance leads to distinct morbidity and mortality with attention paid to the microbial pathogens prevalent between groups

Although early research shows promise, it remains largely experimental, and long-term safety data is still limited

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