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For example, flux through the cytosolic urea cycle pathway, which remains intact in CR hi tumors, activates glycolysis, and supports the production of ribose 5-phosphate by the PPP (47), while intermediates of de novo synthesis of purine nucleotides, such as 5-aminoimidazole-4-carboxamide riboside (AICA riboside), also stimulate catabolism of glucose to pentose products (48)

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