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Blood clots (venous thromboembolism) affect 900,000 Americans each year and result in nearly 100,000 deaths, according to the U.S

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The mesolimbic (reward) dopamine pathway drives the reinforcing effects of tobacco smoking, while the mesocortical (goal-directed) dopamine pathwayincluding the dlPFCis critical for inhibitory control (Wu et al., 2/3 receptor (D 2 R) signaling in dlPFC is associated with cognitive deficits, such as impairments in attention, learning, working memory, and inhibitory control (Arnsten et al., Cigarette smoking has been associated with adverse reproductive outcomes including infertility, subfecundity, early menopause, and menstrual disorders (Department of Health Human Services, A preclinical study has shown that sex steroid hormones are involved in the acquisition of, motivation for, and reinstatement of drug taking