Integron-like elements were surveyed using the IntegronFinder tool (Galaxy Version 2.0.2 + galaxy1) available in the Galaxy platform (Nron et al., 2022)
The main challenge is potential irritation at very high concentrations (above 20%), but formulations between 10-20% are generally safe and effective
Our work fundamentally expands the mechanistic understanding of environmental toxin pathogenesis by connecting metabolic reprogramming, epigenetic modification, and ferroptosis execution, while offering actionable therapeutic strategies for improving animal reproductive health
Furthermore, the excessive accumulation of ROS not only disrupts the process of melanin synthesis, but also destabilises, synthesises and disrupts the circulation of lipids in melanocytes, resulting in damage to the mitochondrial electron transport chain and increased ROS production, creating a vicious cycle and destroying melanocytes [19]
10.1016/j.tips.2025.03.008 87 PiaoY.JinJ.ZhouD.QuanH