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Trained immunity: A program of innate immune memory in health and disease

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Tau phosphorylation and A aggregation are possibly two interlinked mechanisms of antimicrobial protection which could be expected as the interactions between A and Tau are also connected at a molecular level via GSK-3 due to its role in the generation of the A peptide and phosphorylated Tau (Sayas and vila, 2021), a process that can be triggered by the viral stimulation of GSK-3 (Wozniak et al., 2009)

The combined anti-inflammatory and antioxidant effects converge to achieve chondroprotection (Figure 2)