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Inhalation of mainstream cigarette smoke or the vapor phase smoke component, 1,3-butadiene, was shown to promote plaque development in cockerels, but CO or an injection of NNK or solubilized concentrated cigarette smoke condensate from an unventilated 2R1 reference cigarette did not promote plaque development in cockerels

Denlinger-Apte, Ph.D., M.P.H., from the Wake Forest University School of Medicine in Winston-Salem, North Carolina, and colleagues examined whether people who smoke may increase their smoking to compensate for the reduced nicotine levels when smoking VLNCs for prolonged periods

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