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Glutathione is implicated at several levels in the regulation of ethylene biosynthesis, with subsequent impact on stress resistance improvement

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One such agent is Olorofim, a dihydroorotate dehydrogenase inhibitor currently in advanced clinical development, which impairs mitochondrial pyrimidine biosynthesis, leading to defective DNA synthesis and subsequent fungal cell death (Oliver et al., 2016)

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doi: 10.1111/j.1748-1716.2010.02237.x 43

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