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Nevertheless, if its senolytic action has been demonstrated in several diseases such as osteoarthritis 15,16 as well as in neurodegenerative diseases 17 , the effect of ABT-263 is restricted to senescent cells from specific cell types 18 , leading to the necessity to identify new potential senolytics to target senescent cells in age-related diseases

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These approaches are not mutually exclusive

With continued scientific refinement and validation, biologic therapies may ultimately provide durable improvements in function and quality of life by addressing the root causes of disc degeneration rather than offering temporary symptom relief

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