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The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]

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While traditional sleep aids force sedation by suppressing neural activity and often disrupt natural sleep architecture (particularly REM sleep), DSIP supports the bodys endogenous sleep-regulating systems to promote natural, restorative sleep with proper progression through all sleep stages

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Paththamperuma, C