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The question is not which is "best" in the abstract, but which combinations make the most sense for a given situation

Tendon and ligament repair, gastrointestinal mucosal healing, soft tissue recovery, and neuroprotective signaling are all supported by reproducible rodent and in vitro work, while the human evidence remains limited to one unpublished Phase 2 IBD trial and a small number of preliminary studies

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However, injectable administration provides near 100% bioavailability and systemic effects that topical application cannot match