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Interestingly, all the above-mentioned events that promote hepatic fat accumulation are (i) indirectly or directly related to alterations in methionine metabolism and (ii) mitigated by betaine treatment as shown in multiple investigations [23,60,61,81,82,83,90,91,114,115,116], as schematically represented in Figure 2

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Toxicity happens when the level of the toxin goes beyond the robustness&of our body's defense against it

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