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The purpose of elongating the N-terminal acyl group and removing the N-terminal amino group was to increase the probability that resultant molecules might be BBB permeable and access the brain parenchyma

Low levels or poor absorption can limit how effectively these systems operate

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Second, unlike full-length growth hormone, AOD-9604 does not bind to growth hormone receptors present throughout the body

By studying these effects, researchers aim to understand the molecular basis of anti-inflammatory processes at the cellular level