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It also suggests that we need to be more precise when we ask about cigarette smoking frequency." The researchers examined an existing data set from the National Institutes of Health in the US, including more than 6 700 smokers who had been fully assessed to find out if they met the 11 criteria listed in the 5th edition of the Diagnostic and Statistical Manual (DSM-5) for tobacco use disorder

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The amount of pigmentation increases with greater tobacco use, and is more common in females

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