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Epithelial MLCK-dependent barrier dysfunction mediates T-cell activation-induced diarrhea in vivo Cytoskeletal contraction due to myosin II (regulatory)-light chain (MLC) phosphorylation is necessary for barrier disruption and in vitro inhibition of myosin light chain kinase (MLCK) restores barrier function following cytokine treatment

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In addition to nuclear receptor-mediated genomic effects that increase or decrease gene transcription, T 3 can exert non-transcriptional effects via intracytoplasmic THRs or membrane integrin receptor v3 [61]

doi: 10.3390/nu14010107