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This three-pathway anti-inflammatory profile makes the blend of particular interest for research models where systemic or localized inflammatory signaling is the study endpoint, as investigators can evaluate the combined effect against individual component controls

305 At the therapeutic level, therapeutic vaccines targeting Arg 1 have been shown to activate antitumor immunity in a variety of syngeneic mouse tumor models such as lung cancer, melanoma, and colon cancer, and the combination of Arg 1 vaccine with anti-PD-1 antibody can increase T cell infiltration, inhibit myeloid cell function, and increase the ratio of tumor-infiltrating M1/M2 macrophages