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This Research Topic is part of a series with: The changing faces of glutathione, a cellular protagonist., Volume II Glutathione (GSH) has been described for a long time just as a defensive reagent against the action of toxic xenobiotics (drugs, pollutants, carcinogens), both directly and as a cofactor for GSH transferases

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The reduction in GSH concentrations appears to contribute to more severe disease progression and higher mortality risk, particularly among older patients, suggesting that GSH depletion may serve as a potential prognostic marker