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P3: weight loss 2, fat loss 0 (ratio 0.00)

Proc Natl Acad Sci USA 99(16):10831

When there are insufficient quantities of xCT and GPX4, intracellular cystine levels fall

This combination of increased inflammation, reduced regenerative capacity, and cellular senescence lead to increased liver fibrosis and increased vulnerability to injury such as alcohol, drugs, and toxins

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