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Environmental Toxins- Exposure to environmental toxins can contribute to premature aging and skin damage

Although much of the evidence described above come from cellular fractionation studies that will need validation, these findings may explain the mitochondrial dysfunction reported in in vitro and in vivo SCA3 models, namely mtDNA deletions and reduced copy number that are often found in SCA3 cells, transgenic mice, and patients

J.ChangW.MiclauT.et al (2017)

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High intake of fats from sources like cheeses, eggs, butter, oils, and meat can lead to poor tolerance, potentially resulting in a lack of motivation and discontinuation of the diet [198]