The two-electron reducing agent is NADH and the enzyme requires a FAD cofactor close to the active-site Hg-binding cysteines, which operate through a mechanism possibly similar to that of the enzyme glutathione reductase ( vide infra ) [92,93,94]
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In addition, genetic variants in genes encoding for GPXs have been associated with increased mortality from cardiovascular diseases (Zhang et al., 2014) and diabetes (Hamanishi et al., 2004)
doi: 10.4161/cc.22632 34 TanHWSSimAYLLongYC
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